The role of peroxisome proliferator-activated receptor [gamma] in colon cancer and inflammatory bowel disease

From: Archives of Pathology & Laboratory Medicine | Date: September 1, 2003| Author: | Copyright information

* Objective.-Review the role and therapeutic potential of peroxisome proliferator-activated receptor (PPAR) [gamma] in colonic disorders.

Data Sources.-Recent peer-reviewed scientific literature focusing on PPAR [gamma] in the colon.

Study Selection.-Research reports using animal models, cultured cell lines, and clinical material were examined for content related to the role of PPAR [gamma] in normal colon cell function, colon cancer, and inflammatory bowel disease. Issues concerned with potential therapeutic use were also considered.

Data Synthesis.-Key points pertaining to PPAR function and ...

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