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Rapid development of severe copper deficiency in a patient with Crohn's Disease receiving parenteral nutrition
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ABSTRACT. A 32-year-old man with active Crohn's disease and recurrent small bowel strictures underwent abdominal surgery and was subsequently given total parenteral nutrition (TPN). Severe cholestasis developed and copper was removed from the TPN. Although serum ceruloplasmin levels were within normal limits, 8 weeks after copper removal, he developed pancytopenia. Serum copper levels were severely depressed. Bone marrow biopsy was consistent with copper deficiency; cytoplasmic vacuolization of both myeloid and erythroid precursors, megaloblastic erthropoiesis, and marked hypocellularity were ...
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Copper and cardiovascular health.
; ...been a general failure to recognize that copper deficiency is both common in America and a cause...disorders. Such statements as no evidence of copper deficiency or copper deficiency is rare are usual. (10,11) It is becoming...
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Increased rat brain cytochrome c correlates with degree of perinatal copper deficiency rather than apoptosis1
; ...decreased Bcl-2 levels. Perinatal copper deficiency was induced in Holtzman rats during...apoptosis is not enhanced by dietary copper deficiency in the brain. Lower Bcl-2 levels...be correlated with the degree of copper deficiency and seemed to be associated with...
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Abnormal Motor Function Persists Following Recovery from Perinatal Copper Deficiency in Rats1,2
; ...behavioral consequences of perinatal copper deficiency? Pregnant Holtzman rats were fed...rats exhibited signs consistent with copper deficiency. P21 males were switched to a nonpurified...long-term recovery from perinatal copper deficiency. J. Nutr. 134: 1984-1988, 2004. KEY...
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Copper Deficiency Myelopathy (Human Swayback)
; The hematologic manifestations of copper deficiency are well known and include anemia...neurological manifestations of acquired copper deficiency in humans has been recognized, the...ataxia. The known causes of acquired copper deficiency include prior gastric surgery, excessive...
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Pancytopenia after removal of copper from total parenteral nutrition
; ...elements were omitted from her TPN because of cholestasis...19 months of receiving TPN without trace elements...hematologic consequences of copper deficiency, thrombocytopenia rarely...pancytopenia secondary to TPN-related copper deficiency in which the association...total ...
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Latent Copper Deficiency in Patients Receiving Low-Copper Enteral Nutrition for a Prolonged Period
; ABSTRACT. Background: Copper deficiency has been reported in patients...relating to the onset time of copper deficiency and how the symptoms develop...describes the relation between copper deficiency symptoms and duration of...
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Increased Heme Oxygenase-1 Expression during Copper Deficiency in Rats Results from Increased Mitochondrial Generation of Hydrogen Peroxide1-4
; ...in rats is elevated in response to copper deficiency. However, the mechanism responsible...for the induction of HO-1 during copper deficiency. Mitochondria isolated from the livers...copper-deficient rats, indicating that copper deficiency stimulated the expression of the...
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Cardiovascular disease from cooper deficiency-a history
; Cardiovascular Disease from Copper Deficiency-A History1 ABSTRACT Although the...discovery of cardiovascular disease from copper deficiency for more than a decade. Anatomical...impaired defense against free radicals. Copper deficiency also decreases copper in hearts and...
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Decreased Hephaestin Activity in the Intestine of Copper-Deficient Mice Causes Systemic Iron Deficiency1
; ...metabolism intersect in mammals. Copper deficiency simultaneously leads to decreased...the effect of in vivo and in vitro copper deficiency on hephaestin (Heph) expression and...was significantly downregulated by copper deficiency (~60% of controls), and enterocyte...
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Enhanced expression of hepatic genes in copper-deficient rats detected by the messenger RNA differential display method
; ...abundance was enhanced 1.2-fold by copper deficiency, is novel. Four other cDNA fragments...mRNA fetuin mRNA mitochondrial genes copper deficiency rats Enhanced Expression of Hepatic...Most of the symptoms of severe copper deficiency can be explained by failure of one...
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