Intestinal atrophy has a greater impact on nitrogen metabolism than liver by-pass in piglets fed indentical diets via gastric, cental venous or portal venous routes

The Journal of Nutrition | May 1, 1999| | Copyright

Intestinal Atrophy Has a Greater Impact on Nitrogen Metabolism than Liver By-Pass in Piglets Fed Identical Diets via Gastric, Central Venous or Portal Venous Routes1,2

ABSTRACT Whole-body nitrogen metabolism is altered during parenteral feeding as a result of gut atrophy and/or lack of splanchnic first-pass metabolism. We developed in vivo models to describe the metabolic and physiologic effects of first-pass metabolism by the small intestine/liver, liver or non-splanchnic tissues. Fifteen 2to 4-d-old piglets were fed identical diets continuously for 8 d via gastric (IG), portal (IP) or ...

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