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Cholecystokinin-A receptors are involved in food intake suppression in rats after intake of all fats and carbohydrates tested1,2
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Manuscript received 20 December 2002. Initial review completed January 2003. Revision accepted 29 March 2002 .
ABSTRACT The hypothesis of these studies was that all fats and carbohydrates suppress food intake, at least in part, via cholecystokinin-A receptors (CCKAR). Fat (coconut oil, beef tallow, olive and safflower oil) and carbohydrate (cornstarch, sucrose, glucose and fructose) preloads were given intragastrically (1 g/4 mL) 30 min before feeding. Devazepide (0.25 mg/kg), a CCKAR antagonist, was given intraperitoneally at 60 or 30 min before or with each of the macronutrient preloads. ...
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