Herpesvirus 8 inclusions in primary effusion lymphoma: Report of a unique case with T-cell phenotype

From: Archives of Pathology & Laboratory Medicine | Date: March 1, 1999| Author: | Copyright information

* We describe a case of primary effusion lymphoma with T-cell phenotype, mixed genotype, and intranuclear her. pesvirus inclusions visible with the light microscope. Cells were studied by immunohistochemical analysis, in situ hybridization, immunoglobulin and T-cell receptor gene re. arrangement, and polymerase chain reaction. Primary effusion lymphoma cells with T-cell phenotype revealed herpesvirus 8 inclusions predominantly seen in apoptotic cells, suggesting that productive viral infection is associated with cell death. Clinical features were typical of primary effusion lymphoma. ...

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