Origin and history of the IVS-I-110 and codon 39 [beta]-thalassemia mutations in the Lebanese population

From: Human Biology | Date: December 1, 2002| Author: Bouhass, Rachid; Demont, Jocelyne; Et al; Trabuchet, Guy; Zahed, Laila | Copyright information

Abstract Using restriction fragment length polymorphisms (RFLPs) and sequence haplotype analysis, we studied the chromosomal background of the [beta]-globin gene in 31 unrelated Lebanese IVS-I-110 or codon 39 (Cd39) subjects, and five normal [beta]^sup A^/[beta]^sup A^ individuals. Our results are compared with those from similar studies in other parts of the Mediterranean in an attempt to provide insights into historical patterns of selection and disease. The great majority of the Lebanese c...

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