The cystic fibrosis heterozygote advantage: a snythesis of ideas From: Anthropologica | Date: January 1, 1997| Author: | Copyright Wilfrid Laurier University, Department of Sociology and Anthropology 1997. Provided by ProQuest LLC.Copyright information

Abstract: It has been proposed that the high frequency of Cystic Fibrosis (CF) is due to a selective advantage in the heterozygous state. This research supports this proposition and attempts a holistic perspective in reviewing the various models proposed. The pathophysiology, molecular and population genetics and the epidemiology are all demonstrated to be key components when evaluating the carrier advantage of CF.

Various hypotheses are reviewed and critically evaluated. The most recent explanation proposed -- that CF affords protection against cholera -- is a main focus of this research. ...

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