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^sup 89^Zr immuno-PET: Comprehensive procedures for the production of ^sup 89^Zr-labeled monoclonal antibodies
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The use of immuno-PET, the combination of PET with monoclonal antibodies (mAbs), is an attractive option to improve tumor detection and mAb quantification. The long-lived positron emitter ^sup 89^Zr has ideal physical characteristics for immuno-PET, such as a half-life of 3.27 d, which is compatible with the time needed for intact mAbs to achieve optimal tumor-to-nontumor ratios. Thus far, a major limitation in the use of ^sup 89^Zr has been the lack of suitable methods for its stable coupling to mAbs. In this article, practical protocols for reproducible isolation of highly pure ^sup 89^Zr ...
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Practical Dosimetry of Peptide Receptor Radionuclide Therapy with ^sup 90^Y-Labeled Somatostatin Analogs
; ...tetraacetic acid-D-Phe^sup 1^-Tyr^sup 3^-octreotide is usually...therapeutic agent labeled with ^sup 90^Y is not suitable for...surrogate labeled with the positron emitter ^sup 86^Y can be considered the...reasons. In the case Of ^sup 90^Y-DOTATOC, the β-emission of ...
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GRP Receptor-Targeted PET of a Rat Pancreas Carcinoma Xenograft in Nude Mice with a ^sup 68^Ga-Labeled Bombesin(6-14) Analog
; ...analog labeled with the positron emitter ^sup 68^Ga for receptor imaging...13-20). In particular, ^sup 90^Y, ^sup 188^Re, and ^sup 177^Lu have been used to...radiotherapy applications, whereas ^sup 99m^Tc and ^sup 111^In labeling has been...analogs with the short-lived ...
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Pharmacokinetics and Biodistribution of ^sup 111^In- and ^sup 177^Lu-Labeled J591 Antibody Specific for Prostate-Specific Membrane Antigen: Prediction of ^sup 90^Y-J591 Radiation Dosimetry Based on ^sup 111^In or ^sup 177^Lu?
; ^sup 111^In-Labeled antibodies and peptides have...used as chemical and biologic surrogates for ^sup 90^Y-labeled therapeutic agents. However, recent...significant differences in biodistribution between ^sup 111^In- and ^sup 90^Y-labeled agents. Yttrium...
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^sup 99m^Tc-MAEC Complexes: New Renal Radiopharmaceuticals Combining Characteristics of ^sup 99m^Tc-MAG3 and ^sup 99m^Tc-EC
; ^sup 99m^Tc-Mercaptoacetyltriglycine (^sup 99m^Tc-MAG3) and ^sup 99m^Tc-L,L-ethylenedicysteine (^sup 99m^Tc-LL-EC) are useful renal radiopharmaceuticals; however, both agents have renal clearances less than that of ^sup 131^I-orthoiodohippurate...
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Effects of Intracellular and Extracellular Concentrations of Ca^sup 2+^, K+, and Cl- on the Na+-Dependent Mg^sup 2+^ Efflux in Rat Ventricular Myocytes
; ABSTRACT Intracellular Mg^sup 2+^ concentration ([Mg^sup 2+^]^sub i^) was measured in rat ventricular myocytes with...indicator furaptra (25C). After the myocytes were loaded with Mg^sup 2+^, the initial rate of decrease in [Mg^sup 2+^]^sub i^ (initial...
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Development of a Novel ^sup 99m^Tc-Chelate-Conjugated Bisphosphonate with High Affinity for Bone as a Bone Scintigraphic Agent
; In bone scintigraphy using ^sup 99m^Tc with methylenediphosphonate (^sup 99m^Tc-MDP) and hydroxymethylenediphosphonate (^sup 99m^Tc-HMDP), it takes 2-6 h after an injection before imaging can start. This interval could be shortened with a new radiopharmaceutical...
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Processing of Generator-Produced ^sup 68^Ga for Medical Application
; ...example, DOTA-DPhe^sup 1^-Tyr^sup 3^-octreotide (DOTATOC...relative to the eluted ^sup 68^Ga activity, not corrected...Specific activities of ^sup 68^Ga-DOTATOC were 50 MBq...purification of generator-derived ^sup 68^Ga(III) eluates. The...preparation of injectable ^sup 68^Ga-labeled ...
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Low-Affinity Na^sup +^ Uptake in the Halophyte Suaeda maritima1[C][W][OA]
; Na^sup +^ uptake by plant roots has largely been explored using species that accumulate little Na^sup +^ into their shoots. By way of contrast, Nathe...its leaves. Here we report that cAMP and Ca^sup 2+^ (blockers of nonselective cation channels...
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^sup 203^Pb-Labeled [alpha]-Melanocyte-Stimulating Hormone Peptide as an Imaging Probe for Melanoma Detection
; Peptide-targeted α-therapy with 7.4 MBq of ^sup 212^Pb-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-ReO-[Cys^sup 3,4,10^, D-Phe^sup 7^,Arg^sup 11^]α-MSH^sub 3-13^ (^sup 212^Pb-DOTA-Re(Arg^sup 11^)CCMSH...
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^sup 99m^Tc-N-DBODC5, a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance: Comparison with ^sup 99m^Tc-Sestamibi and ^sup 99m^Tc-Tetrofosmin in Rats
; ^sup 99m^Tc-[bis (dimethoxypropylphosphinoethyl)-ethoxyethylamine (PNP5...myocardial uptake and clearance kinetics and organ biodistribution of ^sup 99m^Tc-N-DBODC5 with ^sup 99m^Tc-sestamibi and ^sup 99m^Tc-tetrofosmin. Methods: Seventy-five...
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