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The soybean [beta]-conglycinin [beta] 51-63 fragment suppresses appetite by stimulating cholecystokinin release in rats1
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Manuscript received 28 January 2003. Initial review completed 4 March 2003. Revision accepted 2 June 2003.
ABSTRACT We previously demonstrated that soybean [beta]-conglycinin peptone suppresses food intake and gastric emptying by direct action on rat small intestinal mucosal cells to stimulate cholecystokinin (CCK) release. The aim of the present study was to define the active fragment in [beta]-conglycinin by using synthetic peptides chosen from the sequence of three [beta]-conglycinin subunits. We selected the fragments that had multiple nonadjacent arginine residues, and investigated their ...
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