Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats1,2

From: The Journal of Nutrition | Date: August 1, 2003| Author: | Copyright information

Manuscript received 14 March 2003. Initial review completed 8 April 2003. Revision accepted 15 May 2003.

ABSTRACT We showed previously that vitamin A deficiency per se causes emphysema. Benzo(a)pyrene, a constituent in cigarette smoke, induces vitamin A depletion when administered to rats; therefore, we tested the hypothesis that cigarette smoke induces vitamin A depletion, which is associated with the development of emphysema. Male weanling rats were fed a purified AIN-93G diet and divided into two groups. The experimental group was exposed to cigarette smoke from 20 nonfiltered commercial ...

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