Properties of slow, cumulative sodium channel inactivation in rat hippocampal CA1 pyramidal neurons From: Biophysical Journal | Date: February 1, 1999| Author: Mickus, Timothy; Jung, Hae-yoon; Spruston, Nelson | Copyright Biophysical Society Feb 1999. Provided by ProQuest LLC.Copyright information

ABSTRACT Sodium channels in the somata and dendrites of hippocampal CAl pyramidal neurons undergo a form of long-lasting, cumulative inactivation that is involved in regulating back-propagating action potential amplitude and can influence dendritic excitation. Using cell-attached patch-pipette recordings in the somata and apical dendrites of CAl pyramidal neurons, we determined the properties of slow inactivation on response to trains of brief depolarizations. We find that the amount of slow ...