Touchstone II: A new approach to ab initio protein structure prediction

From: Biophysical Journal | Date: August 1, 2003| Author: | Copyright information

ABSTRACT We have developed a new combined approach for ab initio protein structure prediction. The protein conformation is described as a lattice chain connecting C^sub [alpha]^ atoms, with attached C^sub [beta]^ atoms and side-chain centers of mass. The model force field includes various short-range and long-range knowledge-based potentials derived from a statistical analysis of the regularities of protein structures. The combination of these energy terms is optimized through the maximization of correlation for 30 x 60,000 decoys between the root mean square deviation (RMSD) to native and ...

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