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Selective Cell Targeting with Light-Absorbing Microparticles and Nanoparticles
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ABSTRACT We describe a new method for selective cell targeting based on the use of light-absorbing microparticles and nanoparticles that are heated by short laser pulses to create highly localized cell damage. The method is closely related to chromophore-assisted laser inactivation and photodynamic therapy, but is driven solely by light absorption, without the need for photochemical intermediates (particularly singlet oxygen). The mechanism of light-particle interaction was investigated by nanosecond time-resolved microscopy and by thermal modeling. The extent of light-induced damage was ...
Related newspaper, magazine, and trade journal articles from HighBeam Research
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K-State Physics Professor and Collaborator Use Musical Chords to Analyze and Illustrate Hydrogen Molecule's Response to Laser Pulses
; ...how a hydrogen molecule responds to laser pulses by using the changing musical chord...particle accelerators, Thumm said. The laser pulses offer more control and can be made so...molecules in time. In addition, the laser pulses' peak intensity is enormous and would...
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Photodynamic therapy.(Photodynamic therapy T Patrice)(Book Review)
; Photodynamic therapy T Patrice (ed) Cambridge; Royal Society...seems appropriate when considering photodynamic therapy. Churchill was 29 years old when, in 1904, the term photodynamic therapy was first used by a professor called...
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Nonsurgical Tx Benefits Paget's Disease.(photodynamic therapy for Paget's disease)
; WASHINGTON -- Photodynamic therapy holds great promise as an...local anatomy and function. Photodynamic therapy using topical [delta]-aminolevulinic...1995 to 2001 has now shown photodynamic therapy to be beneficial for this...
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Apoptotic response to photodynamic therapy versus the Bcl-2 antagonist HA14-1
; Apoptotic Response to Photodynamic Therapy versus the Bcl-2 Antagonist...compare the effects of photodynamic therapy (PDT) with those of the...colony-forming ability by 90%; PDT, photodynamic therapy; ROS, reactive oxygen...
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Photodynamic Therapy Slows Esophageal Dysplasia's Progression.
; ATLANTA -- Photodynamic therapy reduces the long-term risk...patients who were treated with photodynamic therapy primarily for high-grade...Center, Knoxville, Tenn. For photodynamic therapy, the photo-sensitizing agent...
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Let there be lightning.(firing laser pulses used to prevent direct strikes)(Brief Article)
; Scientists at France's University of Lyon have discovered how to bring down lightning bolts on demand by firing laser pulses into a storm cloud, which could help protect sensitive installations like airports and electrical plants from direct strikes...
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Direct near-infrared luminescence detection of singlet oxygen generated by photodynamic therapy in cells in vitro and tissues in vivo
; ...Detection of Singlet Oxygen Generated by Photodynamic Therapy in Cells In Vitro and Tissues In...major cytotoxic agent involved in photodynamic therapy (PDT). Measurement of ^sup 1^O^sub...optical parametric oscillator; PDT, photodynamic therapy; PMT, photomultiplier tubePS, ...
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Immunosuppressive effects of silicon phthalocyanine photodynamic therapy
; ...photosensitizer being evaluated for the photodynamic therapy (PDT) of solid tumors, was immunosuppressive...interleukin-I0; Pc, phthalocyanine; PDT, photodynamic therapy; scid, severe combined immune deficient...necrosis factor-alpha. INTRODUCTION Photodynamic therapy (PDT)t shows ...
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Photodynamic therapy for the palliation of esophageal cancer: Expensive endoscopic technique or inexpensive cancer treatment? / In reply
; ...timely. However, their description of photodynamic therapy (PDT) as relatively expensive might...have had external-beam radiation. Photodynamic therapy with porfimer sodium might be characterized...731-738. 2. Lightdale CJ. Role of photodynamic therapy in the management of advanced ...
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Leading Investigators Highlight Advances in Photodynamic Therapy at the American Academy of Dermatology Annual Meeting ; First-Line Treatment for Patients at Risk for Skin Cancer Evaluated for Potential Effectiveness for Wide Array of Dermatologic Needs
; ...Pharmaceuticals, Inc. (NASDAQ GM: DUSA) - Photodynamic Therapy (PDT) was featured as a key topic...than 200 dermatologists attended Photodynamic Therapy - the third annual course on PDT...treatment. "The ongoing focus on Levulan photodynamic therapy as a unique treatment ...
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