Immunologic and histologic observations in reovirus-induced otitis media in the mouse

From: The Annals of Otology, Rhinology & Laryngology | Date: January 1, 1999| Author: | Copyright information

The goals of this study were to develop a mouse model for virally induced otitis media, and to study the immune response to infection. Intranasal inoculation of mice by reovirus was used to induce otitis media. Immunohistochemical evidence for the presence of reovirus in the nasopharynx, eustachian tubes, and middle ears and the amount of infiltrating B-cells and T-cells in those sites were serially evaluated by painlessly sacrificing animals over a 21-day period. Reovirus antigen was detected in the middle ear mucosa by day 4 in 75% of infected animals, and histologic evidence for otitis ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Managing otitis media with effusion in young children. (Otitis Media Guideline Panel)(includes bibliography)
; Purpose and Scope Otitis media (inflammation of the middle ear) is the most...considered: * Acute Otitis Media - fluid in the middle ear accompanied by...material). * Otitis Media with Effusion - fluid in the middle ear without signs...
Definitions, terminology, and classification of otitis media
; ...used terms follow. Otitis media is an inflammation of the middle ear without reference...infection within the middle ear. Otitis media with effusion is...inflammation in the middle ear is characteristic of acute otitis media. Acute ...
Middle ear infections in children: brouhaha over treatment leads to consensus - for now. (otitis media)
; ...infection of the middle ear, or otitis media, have become...nose to the middle ear. As a result...called acute otitis media, which can lead...both forms of otitis media. Researchers...amoxicillin for a middle ear infection were...
Diagnosis and treatment of otitis media.(Disease/Disorder overview)
; ...criteria for acute otitis media include rapid...of symptoms, middle ear effusion, and...isolates from the middle ear fluid of children with acute otitis media. Fever, otalgia...diagnosed. (4) Otitis media with effusion is middle ear effusion ...
Otitis media treatment in the era of antibiotic resistance. (Tips from Other Journals).
; ...modern management of otitis media in children and...of antibiotics. Middle ear infections typically...catarrhalis. Both middle ear inflammation and...diagnosis of acute otitis media. Retraction of...dysfunction and negative middle ear pressure but ...
Otitis Media in Infants and Children
; Otitis Media in Infants and Children...staging systems for otitis media and its complications...microbiological diagnosis of otitis media. New information includes...Diseases of the middle ear originate in the mucus...aspects of serous otitis media in a ...
Acute Otitis Media: Part I. Improving Diagnostic Accuracy.
; Acute otitis media is overdiagnosed...the diagnosis of otitis media; fever and ear pain...Distinguishing acute otitis media from otitis media with effusion is...bulging in acute otitis media and in a neutral...retracted position in otitis media ...
Environmental risk factors and otitis media in children. (adapted from Journal of Pediatrics, November 1993)(Tips from Other Journals)
; ...risk factors have been reported for otitis media with effusion in children, including...identify environmental risk factors for otitis media that could be altered by the family...to four weeks to assess presence of otitis media with effusion by tympanometry, supplemented...associated ...
Otitis media
; ...ear) What is otitis media? Otitis media is inflammation in the middle ear with up to 25...an episode of otitis media.5 One study found...identified in middle ear fluid was the...function.5 In acute otitis media, bacteria are...70 per cent of ...
Role of interleukin-1(beta) in a murine model of otitis media with effusion
; ...1beta, mouse, otitis media with effusion...frequently in middle ear effusion...Endotoxin in middle-ear effusions...with chronic otitis media with effusion...Experimental otitis media with effusion following middle ear inoculation...