Folate deficiency induces a cell cycle-specific apoptosis in HepG2 cells

From: The Journal of Nutrition | Date: January 1, 1999| Author: | Copyright information

Folate Deficiency Induces a Cell Cycle-Specific Apoptosis in HepG2 Cells1 23

ABSTRACT The human hepatoma HepG2 cell line was chosen as a representative of solid tissue-derived cell systems in which folate metabolism and apoptosis induction have not been thoroughly investigated. HepG2 cells were cultivated in the control or folate-deficient media (control media lacking of folate, glycine, thymidine and hypoxanthine) for 4 wk. This resulted in a decrease in intracellular folate levels to 32% of the control within 1 wk, which was followed by growth arrest and greater cell death rates. These ...

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