Transient inhibition of L929 cell mitosis and locomotion by argon ion laser irradiation

In Vitro Cellular & Developmental Biology | February 1, 1998| | Copyright

KARL W. LANKS,1 JIAN-PING GAO.1 AND BAI-TANG LAI

SUMMARY

Argon ion laser irradiation of L929 cells transiently inhibits both entry into and passage through mitosis without affecting clonogenic survival. Anaphase mitotic figures virtually disappear from irradiated cell monolayers although prophase + metaphase mitotic figures can still be identified. The total number of mitotic figures does not change significantly and time-- lapse video recording shows that cells do not enter mitosis following irradiation. This effect is dependent on light dose within the 900-2700 J/cm^sup 2^ range and ...

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