Calcium and cardiac arrhythmias: DADs, EADs, and alternans From: Critical Reviews in Clinical Laboratory Sciences | Date: January 1, 2003| Author: | Copyright CRC Press 2003. Provided by ProQuest LLC.Copyright information

ABSTRACT: Rapid progress has been made in understanding the molecular mechanisms by which calcium ions mediate certain cardiac arrhythmias. Principal advances include imaging of cytosolic calcium in isolated cells and in intact tissues, use of fluorescent indicators and monophasic action potentia ls to record membrane potentials in isolated tissue, and sequencing of the genes that encode critical ion channel proteins. In this review, five types of arrhythmias are discussed where calcium ion currents, or currents controlled by calcium, appear to be responsible for arrythmogenesis. These ...

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