Dual induction of the Epo-Egr-TNF-[alpha] plasmid in hypoxic human colon adenocarinoma produces tumor growth delay

From: The American Surgeon | Date: January 1, 2003| Author: | Copyright information

Gene therapy is a modality for the treatment of solid tumors that involves the introduction of a suicide gene into the tumor cells. Genetic radiotherapy involves the placement of a radiation-sensitive promoter upstream from a suicide gene. Because of their irregular vasculature some solid tumors are chronically hypoxic and hence are resistant to conventional treatment with chemotherapy and ionizing radiation (IR). The purpose of this study was to demonstrate that regional tumor hypoxia could be exploited to improve local tumor control. The cDNA coding the erythropoietin hypoxia-responsive ...

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