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Reactive nitrogen species block cell cycle re-entry through sustained production of hydrogen peroxide
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Endogenous sources of reactive nitrogen species (RNS) act as second messengers in a variety of cell signaling events, whereas environmental sources of RNS like nitrogen dioxide (NO^sub 2^) inhibit cell survival and growth through covalent modification of cellular macromolecules. To examine the effects of RNS on cell cycle progression, murine type II alveolar C10 cells arrested in G0 by serum deprivation were exposed to either NO^sub 2^ or SIN-1, a generator of RNS, during cell cycle re-entry....
Related newspaper, magazine, and journal articles from HighBeam Research
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Monitoring Cell Cycle Distributions in MCF-7 Cells Using Near-Field Photothermal Microspectroscopy
Biophysical Journal
; ABSTRACT Microspectroscopic techniques such as Fourier transform infrared (FTIR) have played an important role in "fingerprinting" the biochemical composition of cellular components. Based on structure and function, complex biomolecules absorb energy in the mid-infrared 955; = 2-20 m) yielding
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Cellulose synthesis is coupled to cell cycle progression at G^sub 1^ in the dinoflagellate Crypthecodinium cohnii
Plant Physiology
; Cellulosic deposition in alveolar vesicles forms the "internal cell wall" in thecated dinoflagellates. The availability of synchronized single cells, the lack of secondary deposition, and the absence of cellulosic cell plates at division facilitate investigation of the possible roles of cellulose
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Fisetin Inhibits the Activities of Cyclin-Dependent Kinases Leading to Cell Cycle Arrest in HT-29 Human Colon Cancer Cells1
The Journal of Nutrition
; ABSTRACT Fisetin, a natural flavonol present in edible vegetables, fruits, and wine, was reported to exert anticarcinogenic effects. The objective of the current study was to examine the effect of fisetin on the cell cycle progression of the human colon cancer cell line HT-29. HT-29 cells were
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Dietary Isothiocyanates Inhibit Caco-2 Cell Proliferation and Induce G^sub 2^/M Phase Cell Cycle Arrest, DNA Damage, and G^sub 2^/M Checkpoint Activation1
The Journal of Nutrition
; ABSTRACT Benzyl isothiocyanate and phenethyl isothiocyanate, two aromatic phytochemicals present in substantial concentrations in edible vegetables of the genus Brassica, were investigated for their effects on Caco-2 cell proliferation. Benzyl and phenethyl isothiocyanate inhibited DNA synthesis,
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CYTOTOXICITY INDUCED BY NIVALENOL, DEOXYNIVALENOL, AND FUMONISIN B^sub 1^ IN THE SF-9 INSECT CELL LINE
In Vitro Cellular & Developmental Biology
; SUMMARY The toxicity of the mycotoxins nivalenol (NIV), deoxynivalenol (DON), and fumonism B^sub 1^ (FB^sub 1^) was studied in the lepidopteran Spodoptera frugiperda (SF-9) cells, by the trypan blue dye-exclusion and 3-(4,5-dimethylthiozole-2-yl)-2,5-biphenyl tetrazolium bromide (MTT) tests, uptake
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Antagonism of Chk1 Signaling in the G^sub 2^ DNA Damage Checkpoint by Dominant Alleles of Cdr1
Genetics
; ABSTRACT Activation of the Chk1 protein kinase by DNA damage enforces a checkpoint that maintains Cdc2 in its inactive, tyrosine-15 (Y15) phosphorylated state. Chk1 downregulates the Cdc25 phosphatases and concomitantly upregulates the Wee1 kinases that control the phosphorylation of Cdc2.
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Multiple Pathways for Suppression of Mutants Affecting G^sub 1^-Specific Transcription in Saccharomyces cerevisiae
Genetics
; ABSTRACT In the budding yeast, Saccharomyces cerevisiae, control of cell proliferation is exerted primarily during G^sub 1^ phase. The G^sub 1^-specific transcription of several hundred genes, many with roles in early cell cycle events, requires the transcription factors SBF and MBF, each composed
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Constitutive E2F expression in tobacco plants exhibits altered cell cycle control and morphological change in a cell type-specific manner
Plant Physiology
; The E2F family plays a pivotal role in cell cycle control and is conserved among plants and animals, but not in fungi. This provides for the possibility that the E2F family was integrated during the development of higher organisms, but little is known about this. We examined the effect of E2F
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Phosphorylation of the Sic1 Inhibitor of B-Type Cyclins in Saccharomyces cerevisiae Is Not Essential but Contributes to Cell Cycle Robustness
Genetics
; ABSTRACT In budding yeast, B-type cyclin (Clb)-dependent kinase activity is essential for S phase and mitosis. In newborn G^sub 1^ cells, Clb kinase accumulation is blocked, in part because of the Sic1 stoichiometric inhibitor. Previous results strongly suggested that G^sub 1^ cyclin-dependent Sic1
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Cell cycle regulation of pulmonary phosphatidylcholine synthesis
American Journal of Respiratory Cell and Molecular Biology
; Pulmonary surfactant phosphatidylcholine (PC) formation increases as alveolar type II cells mature and arrest in G^sub O^/G^sub 1^ state of the cell cycle at late fetal gestation. To determine whether this G^sub O^G^sub 1^ arrest is responsible for the increase in PC synthesis, we investigated the
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