Altered clearance of gadolinium diethylenetriaminepentaacetic acid aerosol from bleomycin-injured dog lungs: Initial observations

From: American Journal of Respiratory and Critical Care Medicine | Date: June 15, 2003| Author: Matsunaga, Naofumi; Ogasawara, Nobuhiko; Tsukuda, Toshinobu; Yuan, Yue; Suga, Kazuyoshi | Copyright information

To characterize altered alveolar transfer to solute in bleomycin (BLM)-injured lungs, eight dogs underwent a gadolinium diethylenetriaminepentaacetic acid aerosol (Gd-AS) magnetic resonance imaging study before and on Days 7 and 40 after tracheal instillation of BLM (0.75 mg) in the left lungs. Consecutive fast-gradient echo magnetic resonance imaging was acquired during and after spontaneous inhalation of 200-mM Gd-AS. The slope (Kep) and clearance half-time (T1/2) of logarithmic regression ...

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