Lipids in blood-brain barrier models in vitro II: Influence of glial cells on lipid classes and lipid fatty acids From: In Vitro Cellular & Developmental Biology | Date: November 1, 2002| Author: | Copyright Society for In Vitro Biology Nov/Dec 2002. Provided by ProQuest LLC.Copyright information

SUMMARY

Lipids of brain tissue and brain microvascular endothelial cells contain high proportions of long-chain polyunsaturated fatty acids (long PUFAs). The blood-brain barrier (BBB) is formed by the brain endothelial cells under the inductive influence of brain cells, especially perivascular glia, and coculture of endothelial cells and glial cells has been used to examine this induction. The objective of this study was to investigate whether C6 glioma cells are able to influence the lipid composition and shift the fatty acid (FA) patterns of the BBB model cell lines RBE4 and ECV304 toward ...

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