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Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor rassf1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells
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SUMMARY
Availability of the complete sequence of the human genome and sequence homology analysis has accelerated new protein discovery and clues to protein function. Protein-protein interaction cloning suggests multisubunit complexes and pathways. Here, we combine these molecular approaches with cultured cell colocalization analysis to suggest a novel complex and a pathway that integrate the mitochondrial location and the microtubular cytoskeleton with chromosome remodeling, apoptosis,...
Related newspaper, magazine, and journal articles from HighBeam Research
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siRNA design service.(NEW Technology)
Bioscience Technology
; New siRNA service offers four siRNAs targeting a gene of choice designed using an algorithm licensed from Novartis Pharmaceuticals, and provided with a guarantee that at least two of the four siRNAs will result in efficient knockdown. The HiPerformance algorithm used differs from most others in
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Silencing of human coronavirus gene expression.(New Products)
Bioscience Technology
; SARS-Coronavirus siRNA Set is specific for the human coronavirus, and allows gene silencing studies of coronavirus replication and cytopathology in mammalian cell culture. The 40 siRNA duplexes in the SARS-Coronavirus Set were designed to target each of the ten identified open reading frames (ORFs)
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Expressed Sequence Tag Analysis of the Dinoflagellate Lingulodinium polyedrum During Dark Phase¶
Photochemistry and Photobiology
; ABSTRACT To collect information on gene expression during the dark period in the luminous dinoflagellate Lingulodinium polyedrum, normalized complementary DNA (cDNA) libraries were constructed from cells collected during the first hour of night phase in a 12:12 h light-dark cycle. A total of 4324
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Molecular characterization of chikungunya virus from Andhra Pradesh, India & phylogenetic relationship with Central African isolates
Indian Journal of Medical Research
; Background & objectives: Chikungunya virus has caused numerous large outbreaks in India. Suspected blood samples from the epidemic were collected and characterized for the identification of the responsible causative from Rayalaseema region of Andhra Pradesh. Methods: RT-PCR was used for
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Applying RNAi technology--opportunities and pitfalls: the methods used at one company optimize each step of the experimental process.(Biochemicals & Kits)
Bioscience Technology
; The revolution that the discovery of RNA interference (RNAi) brought to functional genomics and drug research was marked last year when its discoverers, Andrew Z. Fire and Craig C. Mello, were awarded the Nobel Prize in Physiology or Medicine. RNAi enables targeted gene knockdown by the
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The evolution of Compugen
Jerusalem Post
; Nicky Blackburn Jerusalem Post 10-21-2001 Headline: The evolution of Compugen Byline: Nicky Blackburn Edition; Daily Section: Economics Page: 11 Sunday, October 21, 2001 -- Lior Ma'ayan, VP of commercial operations at Compugen, calls it an evolution, and certainly though it may not be as complex as
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DAWDLE, a Forkhead-Associated Domain Gene, Regulates Multiple Aspects of Plant Development1[W]
Plant Physiology
; Phosphoprotein-binding domains are found in many different proteins and specify protein-protein interactions critical for signal transduction pathways. Forkhead-associated (FHA) domains bind phosphothreonine and control many aspects of cell proliferation in yeast (Saccharomyces cerevisiae) and
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