Physiological fluctuation of the human left ventricle sympathetic nervous system assessed by iodine-123-MIBG

From: The Journal of Nuclear Medicine | Date: October 1, 1998| Author: | Copyright information

It has been proposed that sympathetic nervous system pathophysiology is involved in the development of cardiovascular disorders. Since cardiac adrenergic activity has been difficult to assess in humans, physiological changes in the sympathetic nervous system in the human left ventricle remain unclear. Methods: To determine if age and gender influence the sympathetic nervous function of the left ventricle, 300 angiographically normal subjects (170 men, 130 women; age range 40-79 yr) had '231-metaiodobenzylguanidine (MIBG) cardiac imaging. Regional quantitative analysis of MIBG uptake and ...

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