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The Ca^sup 2+^ dynamics of isolated mouse [beta]-cells and islets: Implications for mathematical models
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ABSTRACT [Ca^sup 2+^]^sub i^ and electrical activity were compared in isolated [beta]-cells and islets using standard techniques. In islets, raising glucose caused a decrease in [Ca^sup 2+^]^sub i^ followed by a plateau and then fast (2-3 min^sup -1^), slow (0.2-0.8 min^sup -1^), or a mixture of
fast and slow [Ca^sup 2+^]^sub i^ oscillations. In [beta]-cells, glucose transiently decreased and then increased [Ca^sup 2+^]^sub i^, but no islet-like oscillations occurred. Simultaneous recordings of [Ca^sup 2+^]^sub i^ and electrical activity suggested that differences in [Ca^sup 2+^]^sub i^ ...
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Inhibition of cAMP-Dependent Protein Kinase under Conditions Occurring in the Cardiac Dyad during a Ca^sup 2+^ Transient
; ...been predicted to experience very high [Ca^sup 2+^] for short periods of time during a Ca^sup 2+^ transient. The dyadic space accommodates...kinases responsible for the regulation of Ca^sup 2+^ handling proteins of the cell. We...
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Mutations in the Ca^sup 2-^/H^sup +^ Transporter CAX1 Increase CBF/DREB1 Expression and the Cold-Acclimation Response in Arabidopsis
; ...increases in cytosolic free calcium concentration ([Ca^sup 2+^]^sub cyt^) are essential for plant responses...low temperature. Subsequent reestablishment of [Ca^sup 2+^]^sub cyt^ to resting levels by Ca^sup 2+^ pumps and C-REPEAT BINDING FACTOR/DEHYDRATION...
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^sup 41^Ca and Accelerator Mass Spectrometry to Monitor Calcium Metabolism in End Stage Renal Disease Patients
; ...by serial measurements of the ratio ^sup 41^Ca/Ca in serum after in vivo labeling of calcium pools with ^sup 41^Ca. We report the preparation of an intravenous...isotope being ^sup 40^Ca. Stable (^sup 42^Ca, ^sup 44^Ca, and ^sup 46^Ca) ...
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Decoding Ca^sup 2+^ Signals in Plants
; Different input signals create their own characteristic Ca^sup 2+^ fingerprints. These fingerprints are distinguished by frequency, amplitude, duration, and number of Ca^sup 2+^ oscillations. Ca^sup 2+^-binding proteins and protein kinases decode these...
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Ca^sup 2+^ Stores Regulate Ryanodine Receptor Ca^sup 2+^ Release Channels via Luminal and Cytosolic Ca^sup 2+^ Sites
; ABSTRACT The free [Ca^sup 2+^] in endoplasmic/sarcoplasmic reticulum Ca^sup 2+^ stores regulates excitability of Ca^sup 2+^ release by stimulating the Ca^sup...
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Spatial Distribution of Ca^sup 2+^ Signals during Repetitive Depolarizing Stimuli in Adrenal Chromaffin Cells
; ...pattern of stimulation. To understand the dynamic and spatial properties of the underlying Ca^sup 2+^ signal, we used pulsed laser Ca^sup 2+^ imaging to capture Ca^sup 2+^ gradients during stimulation by single and repetitive depolarizing stimuli. Short...
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Role of Sarcoplasmic Reticulum and Mitochondria in Ca^sup 2+^ Removal in Airway Myocytes
; ...to determine the influence of the sarco-endoplasmic Ca^sup 2+^-ATPase (SERCA) activity and mitochondria Ca^sup 2+^ uptake on Ca^sup 2+^ homeostasis in airway myocytes. Experimental studies...
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Consequences of Molecular-Level Ca^sup 2+^ Channel and Synaptic Vesicle Colocalization for the Ca^sup 2+^ Microdomain and Neurotransmitter Exocytosis: A Monte Carlo Study
; ...indicate association between voltage-gated Ca^sup 2+^ channels and the vesicle docking...constrain the separation between some Ca^sup 2+^ channels and vesicles to 20 nm or...relationship among the vesicles, the Ca^sup 2+^ channel, and the proteins of the...
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InsP^sub 3^ Signaling Induces Pulse-Modulated Ca^sup 2+^ Signals in the Nucleus of Airway Epithelial Ciliated Cells
; ABSTRACT The phenomenology of nuclear Ca^sup 2+^ dynamics has experienced important...Although several agonists can mobilize Ca^sup 2+^ from storage in the nuclear envelope...compartment (INC), the mechanisms of Ca^sup 2+^ signaling in the nucleus still remain...
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Differential effects of voltage-dependent inactivation and local anesthetics on kinetic phases of CA^sup 2+^ release in frog skeletal muscle
; ABSTRACT In voltage-clamped frog skeletal muscle fibers, Ca^sup 2+^ release rises rapidly to a peak, then decays to...The peak phase has been attributed to a component of Ca^sup 2+^ release induced by Ca^sup 2+^ which is proportionally greater at low voltages...
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