Feedback regulation in the lactose operon: A mathematical modeling study and comparison with experimental data

From: Biophysical Journal | Date: May 1, 2003| Author: | Copyright information

ABSTRACT A mathematical model for the regulation of induction in the lac operon in Escherichia coli is presented. This model takes into account the dynamics of the permease facilitating the internalization of external lactose; internal lactose; [beta]-galactosidase, which is involved in the conversion of lactose to allolactose, glucose and galactose; the allolactose interactions with the lac repressor; and mRNA. The final model consists of five nonlinear differential delay equations with delays due to the transcription and translation process. We have paid particular attention to the ...

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