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MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain
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ABSTRACT In this work, we present the first characterization of the cell lysing mechanism of MSI-78, an antimicrobial peptide. MSI-78 is an amphipathic [alpha]-helical peptide designed by Genaera Corporation as a synthetic analog to peptides from the magainin family. ^sup 31^P-NMR of mechanically aligned samples and differential scanning calorimetry (DSC) were used to study peptide-containing lipid bilayers. DSC showed that MSI-78 increased the fluid lamellar to inverted hexagonal phase trans...
Related newspaper, magazine, and journal articles from HighBeam Research
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Quantification of Cleaved [beta]^sub 2^-Microglobulin in Serum from Patients Undergoing Chronic Hemodialysis
Clinical Chemistry
; Background: Patients on chronic hemodialysis are prone to develop amyloid deposits of misfolded β^sub 2^-microglobulin 946;^sub 2^M) in osteoarticular tissues. β^sub 2^M with various deletions/truncations and chemical modifications has been found together with structurally intact
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Molecular Basis for the Dynamic Strength of the Integrin a^sub 4^B^sub 1^/VCAM-1 Interaction
Biophysical Journal
; ABSTRACT Intercellular adhesion mediated by integrin ?^sub 4sub 1^ and vascular cell adhesion molecule-1 (VCAM-1) plays a crucial role in both the rolling and firm attachment of leukocytes onto the vascular endothelium. Essential to the ?^sub 4sub 1^/VCAM-1 interaction is its mechanical strength
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Electrostatic Sequestration of PIP^sub 2^ on Phospholipid Membranes by Basic/Aromatic Regions of Proteins
Biophysical Journal
; ... 1990), lymphocytes (Mitchell et al., 1986), and hepatocytes (Tran et al., 1993); for a 10-m cell, this corresponds to an effective ... 5-bisphosphate in actin-supported structures. Curr. Biol. 10:743-746. Tran, D., P. Gascard, B. Berthon, K. Fukami, T. Takenawa, F. Giraud ...
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The Rotor Tip Inside a Bearing of a Thermophilic F^sub 1^-ATPase Is Dispensable for Torque Generation
Biophysical Journal
; ABSTRACT F1-ATPaSe is an ATP-driven rotary molecular motor in which the central γ-subunit rotates inside a stator cylinder made of α^sub 3946;^sub 3^ subunits. To elucidate the role of rotor-stator interactions in torque generation, we truncated the γ-subunit at its carboxyl
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Species Having C^sub 4^ Single-Cell-Type Photosynthesis in the Chenopodiaceae Family Evolved a Photosynthetic Phosphoenolpyruvate Carboxylase Like That of Kranz-Type C^sub 4^ Species1
Plant Physiology
; Spatial and temporal regulation of phosphoenolpyruvate carboxylase (PEPC) is critical to the function of C^sub 4^ photosynthesis. The photosynthetic isoform of PEPC in the cytosol of mesophyll cells in Kranz-type C^sub 4^ photosynthesis has distinctive kinetic and regulatory properties. Some
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Thymosin [beta]^sub 4^ Induces a Conformational Change in Actin Monomers
Biophysical Journal
; ABSTRACT Using fluorescence resonance energy transfer spectroscopy we demonstrate that thymosin β^sub 4^ (tβ^sub 4^) binding induces spatial rearrangements within the small domain (subdomains 1 and 2) of actin monomers in solution. Tβ^sub 4^ binding increases the distance between
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Ultrafast Carotenoid-to-Chlorophyll Singlet Energy Transfer in the Cytochrome b^sub 6^f Complex from Bryopsis corticulans
Biophysical Journal
; ... reinhardtti (14) or very inefficient in the Cyt b^sub 6^f complex from M. laminosus (7). Singlet excited-state dynamics of all-tran-α-carotene free in n-hexane Knowledge of the excited-state dynamics of α-carotene in the absence of an energy acceptor ...
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Synthesis and Biodistribution of Radiolabeled [alpha]^sub 7^ Nicotinic Acetylcholine Receptor Ligands
The Journal of Nuclear Medicine
; Our objective was to develop an array of α^sub 7^-selective nicotinic cholinergic receptor (nAChR)-based imaging agents for PET and SPECT. Methods: (2'R)-N-^sup 11^C-Methyl-N-(phenylmethyl)-spiro[1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridin]-5'-amine 1 was synthesized by reaction of
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Insights into the Molecular Mechanism of Rotation in the F^sub o^ Sector of ATP Synthase
Biophysical Journal
; ABSTRACT F^sub 1^F^sub o^-ATP synthase is a ubiquitous membrane protein complex that efficiently converts a cell's transmembrane proton gradient into chemical energy stored as ATP. The protein is made of two molecular motors, F^sub o^ and F^sub 1^, which are coupled by a central stalk. The membrane
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Association of the I^sub [gamma]^ and I^sub [delta]^ Charge Movement with Calcium Release in Frog Skeletal Muscle
Biophysical Journal
; ... Nature. 325:717-720. Rios, E., and G. Pizarro. 1988. Voltage sensors and calcium channels of excitation-contraction coupling. News Physiol. Sci. 3:223-227. Shirokova, N., A. Gonzlez, J. Ma, R. Shirokov, and E. Ros. 1995. Properties and roles of an intramembranous ...
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