An allele of serum amyloidosis A1 associated with amyloid in both Japanese and Caucasians

From: Amyloid | Date: March 1, 2003| Author: | Copyright information

KEY WORDS: AA-amyloidosis, serum amyloid A, polymorphism, Japanese, Caucasian

ABBREVIATIONS: AA = amyloid A, SAA = serum amyloid A, SNP = single nucleotide polymorphism, RA = rheumatoid arthritis, PCR = polymerase chain reaction

Abstract

Serum amyloid A1 (SAA1), one of the two isotypes of acute phase SAA, is the predominant precursor to amyloid A (AA) protein, the chief constituent of fibrillar deposits in reactive (AA) amyloidosis. Prolonged hyperexpression of SAA protein accompanying chronic inflammation is critical to, but seems not to be sufficient for, the development of AA ...

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