Microsatellite instability in colorectal carcinoma: The comparison of immunohistochemistry and molecular biology suggests role for hMLH6 immunostaining

From: Archives of Pathology & Laboratory Medicine | Date: June 1, 2003| Author: | Copyright information

* Context.-Microsatellite instability (MSI) due to defective mismatch repair (MMR) genes has been reported in the majority of colorectal tumors from patients with hereditary nonpolyposis colorectal cancer syndrome and in 10% to 15% of sporadic colorectal cancers. The identification of cancers associated with MSI requires classical molecular testing as the gold standard.

Objective.-The aim of this study was to evaluate the role of immunohistochemistry with antibodies directed against 4 MMR proteins as a screening tool for carcinomas with MSI.

Methods.-In this study, 204 formalin-fixed, ...

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