Adrenocortical responsiveness to adrenocorticotropic hormone is enhanced in chronically food-restricted rats

From: The Journal of Nutrition | Date: September 1, 1998| Author: | Copyright information

Adrenocortical Responsiveness to Adrenocorticotropic Hormone Is Enhanced in Chronically Food-Restricted Rats''2

Eun-Soo Han,3 Ted R. Evans and James F. Nelson

ABSTRACT Chronic food restriction (FR) of rats and mice results in moderate hyperadrenocorticism, which may play a role in activating cellular mechanisms that retard aging. Previously, we reported that the FR-induced hyperadrenocorticism is not due to an activated hypothalamo-pituitary unit. Therefore, we investigated in a series of experiments whether adrenal responsiveness to adrenocorticotropic hormone (ACTH), in vitro and in vivo, ...

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