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Blockade of tissue factor
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Treatment for Organ Injury in Established Sepsis
Blockade of tissue factor before lethal sepsis prevents acute lung injury and renal failure in baboons, indicating that activation of coagulation by tissue factor is an early event in the pathogenesis of acute lung injury and organ dysfunction. We hypothesized that blockade of tissue factor would also attenuate these injuries in established sepsis by prevention of further fibrin deposition and inflammation. Twelve male baboons received h...
Related newspaper, magazine, and journal articles from HighBeam Research
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Transfusion-Related Acute Lung Injury (TRALI)
Anaesthesia and Intensive Care
; SUMMARY A 50-year-old male presented for a Whipple's procedure to excise a pancreatic lesion. Massive transfusion of packed cells and fresh frozen plasma was required. Towards the end of the procedure, the patient developed sudden onset of frank pulmonary oedema and hypotension. A presumptive
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Protective Ventilation Strategies in the Management of Phosgene-Induced Acute Lung Injury
Military Medicine
; Phosgene is a chemical widely used in the plastics industry and has been used in warfare. It produces a life-threatening pulmonary edema within hours of exposure, to which no specific antidote exists. This study aims to examine the pathophysiological changes seen with low tidal volume ventilation
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Ghrelin Attenuates Sepsis-induced Acute Lung Injury and Mortality in Rats
American Journal of Respiratory and Critical Care Medicine
; Rationale: Our study has shown that plasma levels of ghrelin, a stomach-derived peptide, are significantly reduced in sepsis, and that ghrelin administration improves organ blood flow via a nuclear factor (NF954;B-dependent pathway. However, it remains unknown whether Thanjavur S. Ravikumarghrelin
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Transfusion-Related Acute Lung Injury
Mayo Clinic Proceedings
; Transfusion-related acute lung injury (TRALI) is characterized by the sudden development of noncardiogenic pulmonary edema (acute lung injury) after transfusion of blood products. Poor awareness of TRALI outside of the blood transfusion medicine community has led to a serious underestimation of
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Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury
American Journal of Respiratory Cell and Molecular Biology
; Matrix metalloproteinases (MMPs) have been implicated in the tissue injury seen in neutrophil-dependent models of acute lung injury. However, the role of MMPs in macrophage-dependent models of lung injury is unknown. To address this issue, the macrophage-dependent immunoglobulin A immune
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Genomics made functional in ventilator-associated lung injury
American Journal of Respiratory and Critical Care Medicine
; Mechanical ventilation is now recognized as potentially directly harmful to patients with acute lung injury. The benefits of lower tidal volumes to achieve lower airway pressures (and thus reduce lung cell stretch) have been clearly confirmed by the landmark ARDSnet findings (1). Each additional
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Leukotrienes in Acute Lung Injury: A Potential Therapeutic Target?
American Journal of Respiratory and Critical Care Medicine
; A rapidly growing body of literature has begun to clarify the role of plasma membrane-derived mediators, including metabolites of arachidonic acid, sphingomyelin, lysophospholipid, ceramide, and platelet-activating factor (PAF), in the pathogenesis of acute lung injury. For example, PAF causes
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Reciprocal Congenic Lines of Mice Capture the Aliq1 Effect on Acute Lung Injury Survival Time
American Journal of Respiratory Cell and Molecular Biology
; ... to 13.6 Mb. Interestingly, this region maps to, and extends beyond, the distal most ... Angiotensin converting enzyme (Ace), which maps near the center of the interval (105.81 ... Daly MJ, Lander ES. Constructing genetic maps with MAPMAKER/EXP 3.0. Whitehead Institute ...
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Electroporation-mediated Gene Transfer of the Na^sup +^,K^sup +^-ATPase Rescues Endotoxin-induced Lung Injury
American Journal of Respiratory and Critical Care Medicine
; Rationale: Acute lung injury and acute respiratory distress syndrome are common clinical syndromes resulting largely from the accumulation of and inability to clear pulmonary edema, due to injury to the alveolar epithelium. Gene therapy may represent an important alternative for the treatment and
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40. Ropivacaine decreases inflammation in experimental endotoxin-induced lung injury in the rat
Regional Anesthesia and Pain Medicine
; Background: Endotoxin-induced lung injury is a useful experimental model for the investigation and characterization of immunopathogenic changes and mechanisms in acute lung injury. While parts of the molecular mechanisms have already been explored, other details of the inflammatory reactions remain
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