Diagnosis of typhoid fever by the detection of anti-LPS & anti-flagellin antibodies by ELISA

From: Indian Journal of Medical Research | Date: May 1, 1998| Author: | Copyright information

Mary V. Jesudason, G. Sridharan, R. Arulselvan, P. George Babu* & T. Jacob John

In a developing country like ours where typhoid fever is endemic and there are very few microbiology laboratories to provide diagnosis by culture, a search for non culture techniques for rapid and reliable diagnosis continues. The Widal test has a low sensitivity. We have attempted to adapt the well established enzyme linked immunosorbent assay (ELISA) technique to provide a serological test of better sensitivity and specificity. The ELISA described here to detect anti-LPS antibodies was found to have a ...

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