Comparison of polymerase chain reaction with histopathologic features for diagnosis of tuberculosis in formalin-fixed, paraffin-embedded histologic specimens

From: Archives of Pathology & Laboratory Medicine | Date: March 1, 2003| Author: | Copyright information

* Objective.-To investigate the relationship between various histopathologic features and the results of the tuberculosis (TB)-polymerase chain reaction (PCR) method in routinely submitted histologic specimens for the histopathologic diagnosis of TB.

Design.-We used 95 formalin-fixed, paraffin-embedded tissue blocks from 81 patients who were clinically suspected of having TB. We assessed the presence of histopathologic features including well-formed granuloma, poorly formed granuloma, Gaseous necrosis, and Langhanstype giant cells. We performed nested PCR for IS61 10 and Ziehl-Neelsen ...

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