A longitudinal replicate study of immunosuppressive drugs: A College of American Pathologists Study

Archives of Pathology & Laboratory Medicine | March 1, 2003| | Copyright

* Objective.-To identify the sources of analytical variation for cyclosporine and tacrolimus in a 3-year longitudinal study.

Design.-Two extending from whole blood were spiked with cyclosporine and tacrolimus, respectively. One aliquot of cyclosporine and 2 of the tacrolimus pool were distributed in the first and last mailing for years 1999 to 2001. For both drugs, the total variance for each method was partitioned into within- and between-laboatory components.

Setting.-The A and C mailings of the 1999, 2000, and 2001 AACC/CAP [American Association for Clinical Chemistry/College of American ...

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