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P.S. I love you: Implications of phosphatidyl serine (PS) reversal in acute ischemic syndromes
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INVITED COMMENTARY
P.S.* I Love You: Implications of Phosphatidyl Serine (PS) Reversal in Acute Ischemic Syndromes
The concept introduced by Thimister et al. (1) in their investigation of acute myocardial infarction, reported in this issue of The Journal of Nuclear Medicine, is the difference in the mechanism of localization of the radiopharmaceutical annexin A5, compared with that of antimyosin or pyrophosphate (2,3). Both antimyosin and pyrophosphate require loss of integrity of the cell membrane to achieve localization. Annexin AS localizes to the outer leaflet of the intact membrane of ...
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Evaluation of ^sup 18^F-Annexin V as a PET Imaging Agent in an Animal Model of Apoptosis
; Annexin V is a 36-kDa protein...phosphatidylserine lipids in the cell membrane. Because one of...outer cell surface, annexin V has proven useful...developing ^sup 18^F-annexin V as a PET-based...cancer patients. Annexin V is a 36-kDa protein...interior of the cell ...
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Molecular Position of Radiolabels and Its Impact on Functional Integrity of Proteins
; ...on results obtained with a previously developed annexin V-fluorescent dye conjugate used to show apoptotic cells under a microscope (3). Annexin V was first isolated from human placenta (4) and...coagulation factors from the phospholipid membrane (5). Annexins are ubiquitous homologous proteins that bind ...
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Probing the cell peripheral movements by optical trapping technique
; ...direction, suggesting that the protruding cell membrane pushed the bead. The maximum velocities...creation of the gap between the peripheral cell membrane and the actin network underlying it...these phenomena, protrusion of the cell membrane at the leading edge is an indispensable...
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Lipid Vesicles as Membrane Models for Toxicological Assessment of Xenobiotics
; ...have long been appreciated as simple cell membrane models in biochemical and biophysical...Antimicrobial Peptides, Antibiotics, Cell Membrane Damage, Xenobiotics, Phospholipids...INTRODUCTION The basic structure of the cell membrane has many sites for toxicant action...
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Imaging Single Virus Particles on the Surface of Cell Membranes by High-Resolution Scanning Surface Confocal Microscopy
; ...experiments we have demonstrated that the cell membrane exhibits numerous submicrometer-sized...single polyoma VLPs adsorbed onto the cell membrane. Observed VLPs had a mean width of...were randomly distributed across the cell membrane, and no specific interactions were...
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Stochastic Entry of Enveloped Viruses: Fusion versus Endocytosis
; ...binding of receptors on the target cell membrane to glycoproteins, or "spikes," on the...simultaneously initiate direct fusion with the cell membrane. Both fusion and internalization have...nonspecifically adsorbed on the host cell membrane are computed as functions of receptor...
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Laser beam triggers a membrane breach. (laser used to induce expulsion of structures within cell without damaging cell membrane or structures)(Brief Article)
; The cell membrane serves as a tough, flexible barrier that protects a cell from its...low-power laser beam focused on an artificial structure that mimics a cell membrane can trigger the spontaneous ejection of material inside without permanently...
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Transient Confinement Zones: A Type of Lipid Raft?
; ...signaling events are initiated at the cell membrane. To facilitate efficient signal transduction...Singer-Nicolson fluid mosaic model, the cell membrane is considered as a 2-D oriented solution...gold particles to molecules on the cell membrane, the dynamics of a small number of...
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MIT reveals inner lives of red blood cells.(Research News)
; ...Spectroscopy Laboratory are able to see cell membrane vibrations as tiny as a few tens of nanometers. Studying cell membrane dynamics can help scientists gain...sickle cell anemia and cancer. Cell membrane dynamics are just the beginning...
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Electrochemotherapy delivers drugs to tumors
; Bleomycin able to successfully permeate cell membrane, bind to DNA, and destroy tumor cells...because they cannot get through the cell membrane. The drug is not as effective because...researchers thought, would make the cell membrane more permeable by exposing it to electric...
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