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Acute inflammation induces hyporetinemia and modifies the plasma and tissue response to vitamin A supplementation in marginally vitamin A-deficient rats
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Acute Inflammation Induces Hyporetinemia and Modifies the Plasma and Tissue Response to Vitamin A Supplementation in Marginally Vitamin A-Deficient Rats'2
Francisco J. Rosales and A. Catharine Ross45
ABSTRACT Plasma retinol is reduced during numerous infections, and inflammation alters the hepatic synthesis of retinol-binding protein (RBP). In this study, we have investigated the effects of endotoxin-induced inflammation on vitamin A (VA) supplementation in a rat model of marginal VA deficiency. Marginally VA-deficient rats received an intraperitoneal dose of lipopolysaccharide (LPS, n = ...
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Vitamin A-deficient rats have only mild changes in jejunal structure and function
; ...standard rat diet. Weight began to plateau in VA- rats after 42 d, becoming significantly different...Diarrhea did not develop in any study group. VA- rats had clinical signs of vitamin A deficiency...concentrations were negligible in all VA- rats. VA- rats in the 6063 ...
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Iron deficiency and marginal vitamin A deficiency affect growth, hematological indices and the regulation of iron metabolism genes in rats
; ...liver. In cross-sectional studies and VA supplementation trials conducted to determine the...In general, there was no effect of VA supplementation on TIBC or serum ferritin, with the...which serum ferritin was increased by VA supplementation (16). The rat has been used since...
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A low molar ratio of retinol binding protein to transthyretin indicates vitamin A deficiency during inflammation: Studies in rats and a posteriori analysis of vitamin...
; ...previously reported randomized, placebo-controlled trial of VA supplementation in children with acute measles, In rats, both marginal...Beaton et al. 1994, Sommer and West 1996). As a result, VA supplementation is recommended to reduce the prevalence of VA deficiency...
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Vitamin A Repletion in Rats with Concurrent Vitamin A and Iodine Deficiency Affects Pituitary TSH[beta] Gene Expression and Reduces Thyroid Hyperstimulation and Thyroid Size1
; ...The aim of this study was to investigate the effect of VA supplementation (VAS) and/or dietary iodine repletion, alone and in combination...suffer from both VAD and IDD (4,5). Periodic high-dose oral VA supplementation (VAS) is the recommended strategy to control VAD in affected...
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Chronic marginal vitamin A status reduces natural killer cell number and function in aging Lewis rats
; ...surveillance of malignant or other abnormal cells. Little is known of the effects of chronic marginal vitamin A (VA) status or VA supplementation, or their interaction with age, on NK cell number and cytolytic activity. We have conducted a two-factor (diet, age) study...
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Chronic marginal vitamin A status affects the distribution and functin of T cells and natural T cells in aging Lewis rats
; ...deficiency and aging are independently associated with alterations in immune function, the effects of marginal VA status or VA supplementation on the immune system during aging were not studied. A long-term dietary study was conducted in a rat model of aging to...
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Effects of vitamin A on growth of vitamin A-deficient children: Field studies in Nepal
; ...Joanne Katz, Ramesh Adhikari^ and Alfred Sommer ABSTRACT Inconsistencies have been observed in the impact of vitamin A (VA) supplementation on early child growth. To help clarify this issue, a cohort of 3377 rural Nepalese, nonxerophthalmic children 12-60 mo...
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Vitamin A supplementation of vitamin A deficient measles patients lowers the risk of measles-related pneumonia in Zambian children
; ...examined acute measles case fatality in relation to premorbid VA supplementation found no effect (8). A problem with these studies is that...determined on the basis of the RBP/TTR ratio before and after VA supplementation or placebo administration, and the relationship between...
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Vitamin A deficiency among children from low socio-economic status living in different environments in Khartoum State.
; ...depletion. In this study it was thought pertinent also to confirm the recommendations of Mohamed, M. and Hassan, S. (2) that VA supplementation programs should continue fill the economic crisis is solved. Also nation wide surveys are necessary to determine the exact...
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The Components of VARA, a Nutrient-Metabolite Combination of Vitamin A and Retinoic Acid, Act Efficiently Together and Separately to Increase Retinyl Esters in the Lungs of Neonatal Rats1
; ...from P4 to P14 in rats and mice and from 36 wk gestation up to ~2 y in humans (6)]. Previous studies have shown that VA supplementation of pregnant rats can increase lung RE in their offspring (19). However, direct oral supplementation of the offspring may...
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