Detection of chromosomal numerical abnormalities in clinical breast tumour fine-needle aspirations by fluorescence in situ hybridisation (FISH): Refinement of a method

From: British Journal of Biomedical Science | Date: March 1, 1998| Author: | Copyright information

A. H. PATTERSON, D. T. McMANUS* and P. MAXWELL

Abstract: This study sought to refine a fluorescence in situ hybridisation (FISH) technique for the study of numerical chromosome aberrations in cells recovered from breast tumours by fine-needle aspiration (FNA). Such techniques have been used to study numerical aberrations of chromosomes from tumours from many sites. This technique is intended for use in a routine cytopathology laboratory, and no specialised cytogenetics knowledge is necessary. Slide preparation, slide and probe denaturation, and stringency conditions were investigated. We ...

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