The proliferation of mouse mammary epithelial cells in response to specific mitogens is modulated by the mammary fat pad in vitro

From: In Vitro Cellular & Developmental Biology | Date: May 1, 1998| Author: | Copyright information

RUSSELL C. HOVEY, DUNCAN D. S. MACKENZIE, AND THOMAS B. McFADDEN'

SUMMARY

The ability of the murine mammary fat pad to directly stimulate the growth of mammary epithelial cells and to modulate the effects of various mammogenic agents has been investigated in a newly described. hormone- and serum-free coculture system. COMMA-1D mouse mammary epithelial cells were cultured for 5 or 7 d with various supplements in the absence or presence of epithelium-free mammary fat pad explants from virgin female BALB/c mice. Cocultured fat pad stimulated increases in the DNA content of COMMA-ID cultures by ...

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