Photodynamic inactivation of antibiotic resistant strain of Pseudomonas aeruginosa by porphyrins induced by delta-aminolaevulinic acid

From: Indian Journal of Medical Research | Date: September 1, 2002| Author: | Copyright information

Background & objectives: The widespread occurrence of antibiotic resistant strains of Pseudomonas aeruginosa in hospitals is a matter of growing concern. We report the results of a study on photodynamic inactivation of antibiotic resistant strain of P. aeruginosa by 8-aminolaevulinic acid (ALA).

Methods: Exponentially growing P. aeruginosa cells were incubated in growth medium with ALA for various durations. Subsequently, the cells were washed and resuspended in phosphate buffered saline (PBS). These cells were incubated with different concentrations of glutathione (GSH) in PBS for 15 ...

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