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Factor V Leiden with deep venous thrombosis
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CLINICAL PRACTICE: HEMOSTASIS
Factor V Leiden (FVL) is an autosomal co-dominantly inherited Arg^sup 506^-->Gly substitution of the activated protein C cleavage site affecting 5% of the Caucasian population. FVL results in impaired anticoagulant function without procoagulant modification. Heterozygotes experience a seven-fold increase in thrombotic events, whereas homozygotes may incur a 50 to 100 fold increase. Even though patients are at increased risk for deep venous thrombi, the...
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Combined Factor V Leiden and prothrombin genotyping in patients presenting with thromboembolic episodes
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