Technetium-99m-labeled HL91 to identify tumor hypoxia: Correlation with fluorine-18-FDG

The Journal of Nuclear Medicine | January 1, 1998| | Copyright

Technetium-99m HL91 is a potential agent for imaging hypoxic tissue in vivo. A pilot evaluation using a prototype formulation assessed efficacy in tumor imaging and compared results with ^sup 18^F--fluorodeoxyglucose (FDG) PET. Methods: Ten patients with malignant tumors were included. Tumors included carcinoma of the bronchus (n = 3), carcinoma of the thyroid (n = 2), lymphoma (n = 2), soft tissue sarcoma (n = 1), carcinoid (n = 1) and carcinoma of the breast (n = 1). Whole-body planar scans and localized SPECT scans were performed at 1 and 4 hr postinjection of 600 MBq ^sup 99m^Tc HL91. ...

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