Dosimetric framework for therapeutic alpha-particle emitters

The Journal of Nuclear Medicine | December 1, 1997| | Copyright

Alpha-particle emitters are currently being considered for the treatment of metastatic disease. However, the dosimetry of alphaparticle emitters is a challenge because the dimensions of subcellular targets (e.g., the cell nucleus) are of the same order of magnitude as the range of the particle. Hence, a single dose value is often not representative of the dose delivered to a cell population. Here, we propose a dosimetry system that combines the calculational ease of the Medical Internal Radiation Dosimetry (MIRD) system with the additional information provided by microdosimetry. Methods: ...

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