A Monte Carlo model reveals independent signaling at central glutamatergic synapses

From: Biophysical Journal | Date: November 1, 2002| Author: Bartol, Thomas M Jr; Sejnowski, Terrence J; Franks, Kevin M | Copyright information

ABSTRACT We have developed a biophysically realistic model of receptor activation at an idealized central glutamatergic synapse that uses Monte Carlo techniques to simulate the stochastic nature of transmission following release of a single synaptic vesicle. For the a synapse with 80 AMPA and 20 NMDA receptors, a single quantum, with 3000 glutamate molecules, opened approximately 3 NMDARs and 20 AMPARs. The number of open receptors varied directly with the total number of receptors, and the f...

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