Predicting myelotoxicity in radioimmunotherapy: What does dosimetry contribute?

From: The Journal of Nuclear Medicine | Date: November 1, 1997| Author: Zanzonico, Pat; Sgouros, George | Copyright information

Potential radiogenic damage to the hematopoietic bone marrow is the primary dose-limiting toxicity for systemic radionuclide therapy in general and radioimmunotherapy in particular. A variety of approaches have been pursued in an effort to establish a predictive doseresponse relationship for myelotoxicity (1-7). Although such efforts are still in their infancy, a number of tentative conclusions have emerged. First, although no such correlations have been particularly impressive, absorbed dose...

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