Neutrophil transit times through pulmonary capillaries: The effects of capillary geometry and fMLP-stimulation

Biophysical Journal | October 1, 2002| | Copyright

ABSTRACT The deformations of neutrophils as they pass through the pulmonary microcirculation affect their transit time, their tendency to contact and interact with the endothelial surface, and potentially their degree of activation. Here we model the cell as a viscoelastic Maxwell material bounded by constant surface tension and simulate indentation experiments to quantify the effects of (N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-stimulation on its mechanical properties (elastic shear modules and viscosity). We then simulate neutrophil transit through individual pulmonary capillary ...

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