Propylthiouracil: Liver failure: case report

Reactions Weekly | October 25, 2008| | Copyright

A 19-year-old woman developed liver failure after receiving propylthiouracil for Graves' disease. She subsequently died.

The woman was initiated on propylthiouracil treatment [dosage not stated], without ongoing monitoring of liver function tests. Three months later, she presented with nausea, vomiting, abdominal pain and jaundice. Her liver function tests demonstrated a total bilirubin level of 6.5 mg/dL, an AST level of 1747 U/L and an ALT level of 1589 U/L. After 6 days of hospital treatment, she was transferred in acute liver failure, with coagulopathy and stage II enccphalopathy. The new ...

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