Quantitative Analysis of Norepinephrine Transporter in the Human Brain Using PET with (S,S)-^sup 18^F-FMeNER-D^sub 2^

The Journal of Nuclear Medicine | August 1, 2008| | Copyright

(S,S)-^sup 18^F-FMeNER-D^sub 2^ was recently developed as a radioligand for the measurement of norepinephrine transporter imaging with PET. In this study, a norepinephrine transporter was visualized in the human brain using this radioligand with PET and quantified by several methods. Methods: PET scans were performed on 10 healthy men after intravenous injection of (S,S)-^sup 18^F-FMeNER-D^sub 2^. Binding potential relative to nondisplaceable binding (BP^sub ND^) was quantified by the indirect kinetic, simplified reference-tissue model (SRTM), multilinear reference-tissue model (MRTM), and ...

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