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Human herpesvirus 8 reactivation and human immunodeficiency virus Type 1 gp120
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* Context.-Human herpesvirus 8 (HHV-8) is the presumed etiologic agent of Kaposi sarcoma (KS), the most common neoplasm in patients with acquired immunodeficiency syndrome. Current evidence indicates HHV-8 is necessary, but not sufficient, for KS development without the involvement of other cofactors. One potentially important cofactor is human immunodeficiency virus type 1 (HIV-1). Although HIV-1 is not essential for development of KS, studies have shown factors released from HIV-1infected c...
Related newspaper, magazine, and journal articles from HighBeam Research
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Herpesvirus 8 inclusions in primary effusion lymphoma: Report of a unique case with T-cell phenotype
Archives of Pathology & Laboratory Medicine
; * We describe a case of primary effusion lymphoma with T-cell phenotype, mixed genotype, and intranuclear her. pesvirus inclusions visible with the light microscope. Cells were studied by immunohistochemical analysis, in situ hybridization, immunoglobulin and T-cell receptor gene re. arrangement,
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Association of primary pleural effusion lymphoma of T-cell origin and human herpesvirus 8 in a human immunodeficiency virus-seronegative man
Archives of Pathology & Laboratory Medicine
; * We describe a case of an 87-year-old human immunodeficiency virus (HIV)-negative man who developed a primary pleural lymphoma without any identifiable tumor mass associated with human herpesvirus 8 (HHV-8) infection. A large T-cell lymphoma was diagnosed based on morphologic, immunophenotypic,
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Comparative genomic analyses of primary effusion lymphoma
Archives of Pathology & Laboratory Medicine
; Background.-A rare subset of human immunodeficiency virus (HIV) lymphomas, known as primary effusion lymphomas (PELs), are high-grade tumors carrying human herpes virus 8. Mechanisms postulated to contribute to lymphomagenesis include impaired immune surveillance, alterations in hemopoietic
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KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS: Clinical, Diagnostic, and Epidemiological Aspects
Critical Reviews in Clinical Laboratory Sciences
; Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the few viruses proven to be associated with tumorigenesis in humans. Its causal association with all clinical and epidemiological variants of Kaposi's sarcoma (KS) is well established. KSHV is also involved in the pathogenesis of primary
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Virology, pathogenetic mechanisms, and associated diseases of Kaposi Sarcoma--associated herpesvirus (human herpesvirus 8)
Mayo Clinic Proceedings
; Kaposi sarcoma-associated herpesvirus (KSHV) is a recently discovered and characterized member of the herpesvirus family. It is one of a few viruses proved to be associated with tumorigenesis in humans. Its causal association with 4 clinical and epidemiologic variants of Kaposi sarcoma (classic,
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