Anemia of chronic disease: A harmful disorder or an adaptive, beneficial response?

Canadian Medical Association. Journal | August 12, 2008| | Copyright

Clinical paradigms

Anemia of chronic disease is a hypoproliferative anemia that develops in response to systemic illness or inflammation.1 It was first described in the 1930s and was more fully characterized by Cartwright and Wintrobe in the 1950s.2 Although the second most prevalent after anemia caused by iron deficiency, it is the commonest among patients with chronic illness.3 A variety of clinical conditions can lead to anemia of chronic disease, including infection, cancer and autoimmune conditions.

In comprehensive population-based studies, precise estimates of prevalence are difficult ...

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