Herpes simplex virus 2 infection: A risk factor for HIV infection in heterosexuals

From: Indian Journal of Dermatology, Venereology and Leprology | Date: May 1, 2008| Author: Anuradha, K; Singh, H; Gopal, KVT; Rao, G Rama; Ramani, T; Padmaja, Jyothi | Copyright information

Introduction

Genital ulcerative disease is one of the risk factors for acquisition of human immunodeficiency virus (HIV) infection because of the disruption of the epithelial barrier and infiltration by CD4+ lymphocytes which are targets for HIV infection. In the recent decades, prevalence of herpes simplex infection is on the rise [1],[2],[3] and herpes simplex virus 2 (HSV-2) infection is currently the most common cause of genital ulcerative disease. [4],[5],[6] Hence, HSV-2 may act ...

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