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Hypothesis for the influence of fixatives on the chromatin patterns of interphase nuclei, based on shrinkage and retraction of nuclear and perinuclear structures
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BIOMEDICAL ESSAY
Accepted: 21 January 2002
ABSTRACT
Nuclear chromatin patterns are used to distinguish normal and abnormal cells in histopathology and cytopathology. However, many chromatin pattern features are affected by aspects of tissue processing, especially fixation. Major effects of aldehyde and/or ethanol fixation on nuclei in the living state include shrinkage, chromatin aggregation and production of a 'chromatinic rim' . The mechanisms of these effects are po...
Related newspaper, magazine, and journal articles from HighBeam Research
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Spinning nuclei to extreme deformity. (researcher Demetrios G. Sarantites and colleagues discover hyperdeformation in gadolinium-147 nuclei)(Brief Article)
Science News
; The atomic nucleus is typically pictured as a roughly spherical conglomeration of protons and neutrons. But in recent years, researchers have discovered that certain nuclei adopt an elongated, superdeformed shape when they spin rapidly (SN: 7/28/90, p.53). Now, Demetrios G. Sarantites of Washington
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Mie-Type Scattering and Non-Beer-Lambert Absorption Behavior of Human Cells in Infrared Microspectroscopy
Biophysical Journal
; ABSTRACT We report infrared microspectral features of nuclei in a completely inactive and contracted (pyknotic) state, and of nuclei of actively dividing cells. For pyknotic nuclei, the very high local concentration of DNA leads to opaqueness of the chromatin and, consequently, the absence of DNA
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Visible Light Irradiation of Ethidium Bromide-stained Interphase Nuclei Causes DNA-Protein Linking and Structural Stabilization of Nucleoprotein Complexes6
Photochemistry and Photobiology
; ABSTRACT Fixation of DNA and proteins in the isolated rat hepatocyte nuclei stained with ethidium bromide and irradiated with visible light was analyzed in this study. It was shown that irradiation results in the following modifications of higher- level nucleoprotein complexes of interphase
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The mystery of the broken pearl: Tahitian pearl--is it?(Tahitian bead nuclei are composed of shell)
Jewelers Circular Keystone
; Identifying a broken pearl, like the Tahitian shown here, is usually easy, since 99 percent of all Tahitian bead nuclei are composed of shell, which is recognized by its straight growth layers. But the broken bead of this pearl has a random, gritty structure, casting doubt on its origin. Another
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Metabolic Rates in Small Brain Nuclei Determined by High-Resolution PET
The Journal of Nuclear Medicine
; Identification of small nuclei in the brain by PET has been limited by the spatial resolution of conventional scanners. The new detector technology and advanced signal analysis of a high-resolution research tomograph (HRRT) has improved 3-dimensional spatial resolution to 2.2 mm at sufficient
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Distorted nuclei spinning to the same beat. (atomic nuclei)
Science News
; Distorted nuclei spinning to the same beat Only occasionally in any area of science is something really unexpected found, but that seems to be the case in nuclear-structure physics just now. This arresting assertion introduces a report in the July 16 PHYSICAL REVIEW LETTERS concerning the spectra
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The Generation of Cloned Drosophila melanogaster
Genetics
; ABSTRACT We report here the first successful use of embryonic nuclear transfer to create viable adult Drosophila melanogaster clones. Given the generation time, cost effectiveness, and relative ease of embryonic nuclear transplant in Drosophila, this method can provide an opportunity to further
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Double-bladed device simplifies prechopping for phaco
Ophthalmology Times
; Cataract An efficient tool New Product Focus By Robert Forstag Sharp blade can tackle grade 2, 3 nuclei by penetrating the core Tokyo-A new instrument designed for prechopping reduces phacoemulsification time by 50% and is ideal for high-vacuum and laser phaco. The device, called the Akahoshi Combo
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Raman Spectroscopy Detects Biochemical Changes Due to Proliferation in Mammalian Cell Cultures
Biophysical Journal
; ABSTRACT Raman spectra of cells and nuclei from cultures in the plateau (nonproliferating) and exponential (proliferating) phases of growth were measured and show that Raman spectroscopy can monitor changes due to cell proliferation. A simple fitting routine was developed using a basis set (lipid,
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Promising path to heavy nuclei.(Fusion Boost)
Science News
; Making heavy, artificial atomic nuclei has long been part of the program for answering fundamental questions about matter and the universe, but it hasn't been easy. Physicists are looking toward techniques that forge hefty nuclei by fusing lighter, radioactive ones. Now, results of an accelerator
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